The original Church of San Francesco, in Monteleone di Spoleto, must have been of more slender proportions than the current one; the floor was raised during a second phase (late 14th century), reducing by a third the height of the building, which was accessed by the ogival door on the left side; the floor in fact cuts the fresco with the Crucifixion on the left wall, further covered by the opening of a door which leads into the upper order (15th century) of the cloister.

At the same time, the building was further enlarged with the construction of the minor nave, the right wall and the façade with the imposing external portal, in hard and shiny pepper coloured stone. The embrasure of the portal is composed of six fascias: the most external one, with diamond-tipped hexagonal stars, continues in three slender spiral columns spaced by concave nooks; the last two embellish the jambs which rest on two lions bringing food to their cubs. On the right side, the powerful buttresses with sculpted ends give the Church the appearance of a fortified building.

The two-nave interior is separated by stone pillars; the larger is decorated by a wood ceiling painted by Giuseppe Frigerio from Norcia (1760); the smaller nave is covered by groin vaults and ribs. Of the mural decorations many frescoes of the nave remain. An organ of the 16th century is also present with a decorated case and singing tribune.